{"id":9297,"date":"2026-02-02T11:23:35","date_gmt":"2026-02-02T03:23:35","guid":{"rendered":"https:\/\/www.packqc.com\/applications\/bloom-strength-of-soft-gelatin-capsule\/"},"modified":"2026-03-16T10:56:29","modified_gmt":"2026-03-16T02:56:29","slug":"bloom-strength-of-soft-gelatin-capsule","status":"publish","type":"applications","link":"https:\/\/www.packqc.com\/lv\/applications\/bloom-strength-of-soft-gelatin-capsule\/","title":{"rendered":"M\u012bkst\u0101s \u017eelat\u012bna kapsulas zied\u0113\u0161anas iztur\u012bbas test\u0113\u0161ana"},"content":{"rendered":"

Izm\u0113rot m\u012bksto \u017eelat\u012bna kapsulu ziedu stiprums<\/strong> ir b\u016btiska farm\u0101cijas kvalit\u0101tes kontrol\u0113. T\u0101 tie\u0161i atspogu\u013co \u017eelat\u012bna materi\u0101la meh\u0101nisko integrit\u0101ti un konsistenci, nodro\u0161inot kapsulu atbilst\u012bbu gan regulat\u012bvie standarti<\/strong> un pat\u0113r\u0113t\u0101ju v\u0113lm\u0113m. \u0160aj\u0101 rakst\u0101 apl\u016bkoti ziedu iztur\u012bbas pamati, k\u0101 to p\u0101rbaud\u012bt un k\u0101p\u0113c, izv\u0113loties uzticamu apr\u012bkojumu, piem\u0113ram, CHT-01 \u017eelat\u012bna kapsulas ciet\u012bbas testeris<\/strong><\/a> no Cell Instruments ir \u013coti svar\u012bgi, lai ieg\u016btu uzticamus rezult\u0101tus.<\/p>\n\n\n\n

Izpratne par \u017eelat\u012bna kapsulu zied\u0113\u0161anas stiprumu<\/h2>\n\n\n\n

Zied\u0113\u0161anas sp\u0113ks<\/strong> ir \u017eelat\u012bna stingr\u012bbas jeb \u017eelejas stipr\u012bbas r\u0101d\u012bt\u0101js, kas tie\u0161i ietekm\u0113 \u017eelat\u012bna elast\u012bbu, iztur\u012bbu pret pl\u012bsumiem un \u0161\u0137\u012b\u0161anas \u012bpa\u0161\u012bbas. m\u012bkst\u0101s \u017eelat\u012bna kapsulas<\/strong>. Termins c\u0113lies no Bl\u016bma testa, ar kuru m\u0113ra svaru gramos, kas nepiecie\u0161ams standarta virzulim, lai noteiktos apst\u0101k\u013cos (parasti 10 \u00b0C temperat\u016br\u0101 p\u0113c 17-18 \u017eelet\u0113\u0161anas stund\u0101m) \u017eelat\u012bna \u017eelat\u012bna virsmu nospiestu par 4 mm.<\/p>\n\n\n\n

Saist\u012bb\u0101 ar m\u012bkstaj\u0101m \u017eelat\u012bna kapsul\u0101m augsta ziedu iztur\u012bba parasti nor\u0101da uz ciet\u0101ku un elast\u012bg\u0101ku kapsulas apvalku, kas veicina lab\u0101ku produkta stabilit\u0101ti, meh\u0101nisko iztur\u012bbu iepako\u0161anas laik\u0101 un lab\u0101ku z\u0101\u013cu izdal\u012b\u0161an\u0101s kontroli.<\/p>\n\n\n\n

Bloom stipr\u012bbas test\u0113\u0161anas noz\u012bme farm\u0101cijas kvalit\u0101tes kontrol\u0113<\/h2>\n\n\n\n

The m\u012bksto \u017eelat\u012bna kapsulu ziedu stiprums<\/strong> konsekventi j\u0101uzrauga \u0161\u0101du iemeslu d\u0113\u013c:<\/p>\n\n\n\n

    \n
  • Produktu kvalit\u0101tes nodro\u0161in\u0101\u0161ana<\/strong>: Nodro\u0161ina kapsulas struktur\u0101lo integrit\u0101ti.<\/li>\n\n\n\n
  • Atbilst\u012bba normat\u012bvajiem aktiem<\/strong>: Atbilst USP un EP farmakopejas standartiem.<\/li>\n\n\n\n
  • Formulas stabilit\u0101te<\/strong>: Identific\u0113 at\u0161\u0137ir\u012bbas neapstr\u0101d\u0101ta \u017eelat\u012bna partij\u0101s.<\/li>\n\n\n\n
  • Pat\u0113r\u0113t\u0101ju dro\u0161\u012bba<\/strong>: Nodro\u0161ina, ka kapsulas nesadal\u0101s priek\u0161laic\u012bgi vai ne\u0161\u0137\u012bst p\u0101r\u0101k l\u0113ni.<\/li>\n<\/ul>\n\n\n\n

    \u0160ie kvalit\u0101tes krit\u0113riji ir \u012bpa\u0161i svar\u012bgi attiec\u012bb\u0101 uz z\u0101l\u0113m, kas ir jut\u012bgas pret temperat\u016bru vai mitrumu.<\/p>\n\n\n\n

    Izmantotie instrumenti: M\u012bkst\u0101s \u017eelat\u012bna kapsulas Bloom stipr\u012bbas tests<\/h2>\n\n\n\n

    Zied\u0113\u0161anas testeris - \u017eelat\u012bna \u017eelejas stipruma m\u0113r\u012b\u0161ana<\/h3>\n\n\n\n

    A zied\u0113\u0161anas testeris<\/strong> nov\u0113rt\u0113 \u017eelat\u012bna gela meh\u0101nisko iztur\u012bbu, kas ir cie\u0161i saist\u012bta ar kapsulas darb\u012bbu. \u0160is tests ietver:<\/p>\n\n\n\n

      \n
    • \u017delat\u012bna \u0161\u0137\u012bduma pagatavo\u0161ana (6,67% w\/w),<\/li>\n\n\n\n
    • G\u0113la kondicion\u0113\u0161ana 10\u00b0C \u00b10,1\u00b0C temperat\u016br\u0101 16-18 stundas,<\/li>\n\n\n\n
    • Standarta virzu\u013ca (12,7 mm) pielieto\u0161ana pretest\u012bbas m\u0113r\u012b\u0161anai (gramos).<\/li>\n<\/ul>\n\n\n\n

      Lai gan \u0161aj\u0101 test\u0101 galven\u0101 uzman\u012bba tiek piev\u0113rsta neapstr\u0101d\u0101ta \u017eelat\u012bna \u012bpa\u0161\u012bb\u0101m, tas ir \u013coti svar\u012bgs izejvielu nov\u0113rt\u0113\u0161anai kapsulu ra\u017eo\u0161an\u0101.<\/p>\n\n\n\n

      \u017delat\u012bna kapsulas ciet\u012bbas tests - gala produkta nov\u0113rt\u0113\u0161ana<\/h3>\n\n\n\n

      Kad kapsulas ir izveidotas, to ciet\u012bba<\/strong> un pretest\u012bba sp\u0113kam<\/strong> j\u0101apstiprina, izmantojot \u017eelat\u012bna kapsulas ciet\u012bbas tests<\/strong>. \u0160aj\u0101 test\u0101 kapsulas apvalks tiek iedarbin\u0101ts ar sp\u0113ku, l\u012bdz rodas deform\u0101cija vai pl\u012bsums, imit\u0113jot iepakojuma, uzglab\u0101\u0161anas un nor\u012b\u0161anas laik\u0101 radu\u0161os stresu.<\/p>\n\n\n\n

      Viens no efekt\u012bv\u0101kajiem r\u012bkiem \u0161aj\u0101 jom\u0101 ir CHT-01 \u017eelat\u012bna kapsulas ciet\u012bbas testeris<\/strong> no \u0160\u016bnu instrumenti<\/strong>.<\/p>\n\n\n\n

      \u017delat\u012bna kapsulu ciet\u012bbas test\u0113\u0161anas proced\u016bra<\/h2>\n\n\n\n

      Parauga sagatavo\u0161ana<\/h3>\n\n\n\n
        \n
      • Not\u012briet kapsulas un kondicion\u0113jiet t\u0101s 20-25 \u00b0C temperat\u016br\u0101 ar 50% relat\u012bvo mitrumu.<\/li>\n\n\n\n
      • Pirms test\u0113\u0161anas p\u0101rliecinieties, ka nav redzamu defektu.<\/li>\n<\/ul>\n\n\n\n

        Testa izpilde<\/h3>\n\n\n\n
        \n